GUI Development

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(Python standard library) The standard Python interface to the Tcl/Tk GUI toolkit.
A library for creating NUI applications, running on Windows, Linux, Mac OS X, Android and iOS.
A Simple GPU accelerated Python GUI framework
A modern and customizable python UI-library based on Tkinter.
A Python native, OS native GUI toolkit.
A blending of the wxWidgets C++ class library with the Python.
A cross-platform windowing and multimedia library for Python.
Creating beautiful user-interfaces with Declarative Syntax like QML.
Python Bindings for GLib/GObject/GIO/GTK+ (GTK+3).
Qt for Python offers the official Python bindings for Qt, this is same as PyQt but it's the official binding with different licensing.
Python bindings for the Qt cross-platform application and UI framework.

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